(3-Methoxy-2-nitro-phenyl)-methyl-amine synthesis

4synthesis methods

Product Name:(3-Methoxy-2-nitro-phenyl)-methyl-amine
CAS Number:1143575-95-4
Molecular formula:C8H10N2O3
Molecular Weight:182.18

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74-89-5 Synthesis

74-89-5
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1143575-95-4
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Yield:-

Reaction Conditions:

in methanol for 10 h;Reflux;

Steps:

69
3-Fluoro-2-nitroanisole (4.5 g; Apollo) was mixed with methylamine (50 ml_, 27% w/w solution in MeOH) and the mixture was heated to reflux for 10 hr. After cooling to room temperature the solvent was evaporated to give the title compound (4.0 g).

References:

GLAXO GROUP LIMITED;BLUNT, Richard;EATHERTON, Andrew John;GARZYA, Vincenzo;HEALY, Mark Patrick;MYATT, James;PORTER, Roderick Alan WO2011/12622, 2011, A1 Location in patent:Page/Page column 75

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

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1143575-95-4
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References

4920-80-3
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References

(3-Methoxy-2-nitro-phenyl)-carbamic acid tert-butyl ester

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1143575-95-4
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References