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3-Methoxy-4-Methyl-1,5-naphthyridine synthesis

6synthesis methods
-

Yield:893566-31-9 68%

Reaction Conditions:

with ferrous(II) sulfate heptahydrate;sulfuric acid;sodium 3-nitrobenzene sulfonate;boric acid in water at 135 - 145; for 6 h;Large scale reaction;Skraup reaction;

References:

Li, Bryan;Magee, Thomas V.;Buzon, Richard A.;Widlicka, Daniel W.;Bill, Dave R.;Brandt, Thomas;Cao, Xiaoping;Coutant, Michael;Dou, Haijian;Granskog, Karl;Flanagan, Mark E.;Hayward, Cheryl M.;Li, Bin;Liu, Fengwei;Liu, Wei;Nguyen, Thuy-Trinh;Raggon, Jeffrey W.;Rose, Peter;Rainville, Joseph;Reilly, Usa Datta;Shen, Yue;Sun, Jianmin;Wilcox, Glenn E. [Organic Process Research and Development,2012,vol. 16,# 5,p. 788 - 797] Location in patent:experimental part