3-methoxy-4-methylphenol synthesis
- Product Name:3-methoxy-4-methylphenol
- CAS Number:19217-50-6
- Molecular formula:C8H10O2
- Molecular Weight:138.16
18278-34-7
240 suppliers
$16.00/250mg
19217-50-6
37 suppliers
$175.00/500mg
Yield: 89%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in ethanol;acetic acid at 20; under 3102.97 Torr; for 14 h;
Steps:
82.G
Step G A mixture of Pd/C (1 g, 10% Pd on activated C, 0.94 mmol) and the aldehyde (3.9 g, 25.658 mmol) in EtOH (75 mL) and glacial AcOH (15 mL) is stirred at r. t. under H2 atmosphere (60 psi) overnight (c. a. 14 h). The mixture is filtered through Celite, and the solvent is removed in a rotatory evaporator. The crude residue is purified by flash chromatography on Si02 (15% EtOAc/hexanes) to afford 3.14 g of 4-methyl-3- methoxyphenol (89%, colorless oil).
References:
ELI LILLY AND COMPANY WO2005/37763, 2005, A1 Location in patent:Page/Page column 128
16452-01-0
131 suppliers
$6.00/100mg
19217-50-6
37 suppliers
$175.00/500mg
13120-77-9
213 suppliers
$5.00/5g
19217-50-6
37 suppliers
$175.00/500mg