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ChemicalBook CAS DataBase List 3-Methoxy-5-trifluroMethyl benzonitrile

3-Methoxy-5-trifluroMethyl benzonitrile synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 20 °C
2.1: hydrogenchloride / water; tetrahydrofuran / 1 h / 20 °C
2.2: 0 - 20 °C
3.1: N,N-dimethyl-formamide / 24 h / 100 °C

References:

Glaxo Group Limited;Wan, Zehong;Long, Kai;Sang, Yingxia;Su, Xiaobo US2014/179715, 2014, A1