3-Methyl-3-Pyrrolidinol hydrochloride synthesis
- Product Name:3-Methyl-3-Pyrrolidinol hydrochloride
- CAS Number:921592-91-8
- Molecular formula:C5H12ClNO
- Molecular Weight:137.61
96567-93-0
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921592-91-8
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Yield: 100%
Reaction Conditions:
with hydrogenchloride;hydrogen;palladium diacetate in methanol;water for 2 h;
Steps:
25.B
To a solution of intermediate 25A (2.0 g, 11 mmol) in MeOH (20 ml), was added 25% hydrochloric acid to acidify the reaction followed by palladium acetate (50 mg). Hydrogen was gently bubbled into the reaction while it was agitated in a sonnication bath for a period of 2 h after which time the reaction was filtered through Hyflo and concentrated to afford the title product (1.5 g, quant) as a brown solid. MS: 102.1 (MH+).
References:
Aebi, Johannes;Binggeli, Alfred;Green, Luke;Hartmann, Guido;Maerki, Hans P.;Mattei, Patrizio;Ricklin, Fabienne;Roche, Olivier US2009/29963, 2009, A1 Location in patent:Page/Page column 16
412278-02-5
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921592-91-8
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917-64-6
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101385-93-7
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921592-91-8
64 suppliers
$20.00/100mg