3-methyl-7-Quinolinol synthesis

Yield:851985-87-0 84%

Reaction Conditions:

with water;hydrogen bromide for 120 h;Heating / reflux;

Steps:

27

Description 27; 3-Methvlquinolin-7-ol; A mixture of Description 26 (6.0 g, 34.6 mmol) and 48% aqueous HBr (150 ml) was heated at reflux for 5 days. The mixture was cooled and basified by the careful addition of 33% aqueous ammonia. The resulting precipitate was removed by filtration, washed with water, and dried in-vacuo to give the title compound as a pink solid (4.6 g, 84%). 1H NMR (400 MHz, DMSO-d6) 2. 41 (3 H, s), 7.13 (1 H, dd, J8. 8 and 2.4), 7.22 (1 H, d, J2.4), 7.71 (1 H, d, J8. 8), 7.96 (1 H, t, J0. 7), 8.61 (1 H, d, J2.2), 10. 01 (1 H, s).

References:

WO2005/47279,2005,A1 Location in patent:Page/Page column 35