3-Methyl-tetrahydro-pyran-4-ol synthesis
- Product Name:3-Methyl-tetrahydro-pyran-4-ol
- CAS Number:89534-37-2
- Molecular formula:C6H12O2
- Molecular Weight:116.1583
131067-76-0
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89534-37-2
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Yield:89534-37-2 76%
Reaction Conditions:
with methanol;sodium tetrahydroborate at 0 - 20; for 1 h;
Steps:
3-Methyltetrahydro-2H-pyran-4-ol (D183)
To a solution of 3-methyldihydro-2H-pyran-4(3H)-one (1 .0 g, 8.9 mmol) in MeOH (20 mL) was added slowly NaBH4(410 mg, 10.7 mmol) at 0-5 °C. The reaction solution was stirred at the same temperature for 1 hr. Water (3 mL) was added with dropwise for 10 min. The reaction solution was concentrated in vacuo to give residue. CH2CI2 (15 mL) was added and filtered, the filtrate was concentrated to afford the title compound (780 mg, 76% yield) as a colorless oilsolid.
References:
WO2019/12093,2019,A1 Location in patent:Page/Page column 154
50-00-0
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107-01-7
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1779-22-2
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89534-37-2
16 suppliers
$115.00/50mg