3-METHYLISOXAZOL-4-AMINE synthesis
- Product Name:3-METHYLISOXAZOL-4-AMINE
- CAS Number:354795-62-3
- Molecular formula:C4H6N2O
- Molecular Weight:98.1
1285517-11-4
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Yield:354795-62-3 93%
Reaction Conditions:
with trifluoroacetic acid in dichloromethane at 20; for 1 h;
Steps:
56 Preparation of 3-methylisoxazol-4-amine
[0268j A mixture of tert-butyl (3-methylisoxazol-4-yl)carbamate (150 mg, 0.75 mmol) in TFA/DCM (10 mL, 1:1) was stirred at rt for 1 h. After concentrated, the residue was dissolved in DCM (20 mL) and solid K2C03 (1 g) was added. The solid was filtered off and the filtrate was concentrated to give crude title product (96 mg, yield: 93%), which was used in nest step without further purification.
References:
WO2015/89337,2015,A1 Location in patent:Paragraph 0268
1122-05-0
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