3-METHYLPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER synthesis
- Product Name:3-METHYLPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER
- CAS Number:41110-29-6
- Molecular formula:C7H8N2O2
- Molecular Weight:152.15
67-56-1
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41110-29-6
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Yield: 87%
Reaction Conditions:
with sulfuric acid at 0 - 60; for 4 h;Inert atmosphere;
Steps:
A Step A:
Methyl 3-methylpyrazine-2-carboxylate.
To a solution of 3-methylpyrazine-2-carboxylic acid (6 g, 43.4 mmol, 1 equiv) in methanol (60 mL) at 0° C. was added H2SO4 (2.9 mL, 54.3 mmol, 1.25 equiv) dropwise, and the reaction mixture was stirred at 60° C. for 4 h.
The solvent was evaporated, and the residue was dissolved in water (5 ml) and basified with a 10% aq. Na2CO3 solution to pH 12.
The solution was extracted with AcOEt.
The combined organic layers were dried over MgSO4, filtered and the solvents evaporated under vacuum to give the title compound (5.75 g, 37.8 mmol, 87%), which was used in the next step without further purification. 1H NMR (300 MHz, CDCl3) δ 8.61 (s, 1H), 8.51 (s, 1H), 4.01 (s, 3H), 2.85 (s, 3H).
References:
JANSSEN PHARMACEUTICA NV;GELIN, Christine US2020/392155, 2020, A1 Location in patent:Paragraph 0172; 0209-0210
41110-28-5
130 suppliers
$8.00/250mg
41110-29-6
86 suppliers
$9.00/250mg