3-NITROBENZOIC-D4 ACID synthesis
- Product Name:3-NITROBENZOIC-D4 ACID
- CAS Number:78399-78-7
- Molecular formula:C7H2D4NO4
- Molecular Weight:172.1515
1079-02-3
100 suppliers
$60.00/250mg
78399-78-7
11 suppliers
$495.56/5MG
Yield:78399-78-7 70%
Reaction Conditions:
with sulfuric acid;nitric acid at 0 - 20; for 2 h;
Steps:
8.i Step (i) 3-Nitrobenzoic-2,4,5,6-d4 acid
To a stirred solution of benzoic-2,3,4,5,6-d5 acid (5.0 g, 39.32 mmol, CAS 1079-02-3, from QMX) in concentrated H2SO4 (15 mL, 3 volumes) was added concentrated HNO3 (5 mL, 1 volume) dropwise at 0 °C. The reaction mixture was slowly warmed to rt and stirred for 2 h. The mixture was slowly poured into ice-cold water (500 mL), and a precipitate was collected by suction filtration. The solid was washed with cold water and dried under reduced pressure to afford 3-nitrobenzoic-2,4,5,6-d4 acid (4.75 g, 27.77 mmol, 70% yield). 2H NMR (61.44 MHz, DMSO, traces of DMSO-d6 added) d ppm: 8.64 (s, 1D), 8.46 (s, 1D), 8.36 (s, 1D), 7.83 (s, 1D).
References:
WO2020/212351,2020,A1 Location in patent:Page/Page column 47
78399-79-8
13 suppliers
$195.00/10mg
78399-78-7
11 suppliers
$495.56/5MG
99-05-8
509 suppliers
$14.00/5g
78399-78-7
11 suppliers
$495.56/5MG