(3-nitrobenzyl)hydrazine synthesis

Yield:51421-22-8 92%

Reaction Conditions:

with potassium carbonate;hydrazine hydrate in ethanol at 45; for 8 h;

Steps:

1-(3-nitrobenzyl)hydrazine

1-(Chloromethyl)-3-nitrobenzene (6.5 g, 38 mmol) was added into the solution of hydrazine hydrate(80%, 6.0 g, 112 mmol),60 mL ethanol and potassium carbonate (9.6 g). After the reation mixture was stirred at 45 for 8 hr, EtOH was recoveredand the residue was added 100 mL water. CH2Cl2 (3×50mL) was used to extract the dydrazine and the product was obtainedafter CH2Cl2 was evaporated in cacuo to give a clear yellowish oil of sufficient purity to be used directly in the next step (5.8g, 92% yield).( [33] Wada Katsuaki, et al. N1-((Pyrazol-1-Ymethyl)-2-methylphenyl)-Phatalamide Derivatives And RelatedCompounds Insecticides. WO2005095351. 2005-10-13)

References:

Shang, Zhenhua;Chu, Qianqian;Tan, Sheng [Synthesis,2015,vol. 47,# 7,p. 1032 - 1040] Location in patent:supporting information