ChemicalBook CAS DataBase List 3-nitropyrazolo[1,5-a]pyrimidin-5(4H)-one

3-nitropyrazolo[1,5-a]pyrimidin-5(4H)-one synthesis

2synthesis methods

Product Name:3-nitropyrazolo[1,5-a]pyrimidin-5(4H)-one
CAS Number:1919868-75-9
Molecular formula:C6H4N4O3
Molecular Weight:180.12

29274-22-4 Synthesis

29274-22-4
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3-nitropyrazolo[1,5-a]pyrimidin-5(4H)-one

1919868-75-9
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Yield:1919868-75-9 82%

Reaction Conditions:

with nitric acid at 80; for 3 h;

Steps:

3-nitropyrazolo [1,5-a] pyrimidin-5 (4H) -one

Pyrazolo [1,5-a] pyrimidin-5 (4H) -one (30 g, 191.1 mol) was added in portions to nitric acid (68%) (150 mL) at room temperature, heated to 80 ° C for 3 hours , LCMS monitors the reaction is complete, after the reaction system is cooled to room temperature, filtered,The filter cake was washed with water, methanol and dried to give 3-nitropyrazolo [1,5-a] pyrimidin-5 (4H) -one as a red solid (28g, yield: 82%).

References:

CN111039947,2020,A Location in patent:Paragraph 0121-0122; 0135-0137

1224944-43-7
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1919868-75-9
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References