3-O-Benzyl 17α-Estradiol synthesis
- Product Name:3-O-Benzyl 17α-Estradiol
- CAS Number:23880-59-3
- Molecular formula:C25H30O2
- Molecular Weight:362.5
57-91-0
297 suppliers
$35.00/25mg
100-39-0
432 suppliers
$10.00/10g
23880-59-3
8 suppliers
$70.00/2mg
Yield:23880-59-3 11.9 g
Reaction Conditions:
with potassium carbonate in acetone at 0 - 10; for 2 h;Reflux;
Steps:
3
10 g (39 mmol) of 17-alpha-estradiol (1) is dissolved in 200 ml of dry acetone. 20 g (78 mmcl) of potassium carbonate isadded to the resulting solution and then carefully drop 11.4 g (66 mmcl) of benzyl bromide at 0-10 °C to it. The resulting suspension is stirred for 2 hours at reflux temperature. The suspension is filtered, washed with acetone and the filtrate is evaporated. The resulting crude productis crystallized from hexane. Product: 11.9 g off-white, solid substance.
References:
WO2013/98570,2013,A1 Location in patent:Page/Page column 15