3-O-Benzyl Estratetraenol synthesis
- Product Name:3-O-Benzyl Estratetraenol
- CAS Number:23880-57-1
- Molecular formula:C25H28O
- Molecular Weight:344.49
1150-90-9
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100-44-7
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23880-57-1
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$140.00/5mg
Yield:23880-57-1 85%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide; for 8 h;Inert atmosphere;
Steps:
3 Synthesis of (8S, 9S, 13R, 14S) -3- (benzyloxy) -13-methyl-7,8,9,11,12,13,14,15-octahydro-6H- cyclopenta [a] phenanthrene (3)
Compound 2 (83 mg, 0.326 mmol) was added to a two-necked round-bottom flask substituted with argon gas, diluted with anhydrous DMF, and then potassium carbonate (K2CO3, 225 mg, 1.63 mmol) and benzyl chloride , 0.978 mmol) was added thereto, followed by stirring for 8 hours. After removal of the DMF, the reaction mixture was diluted with water and extracted several times with methylene chloride. The obtained organic layer was dried with water, a sodium sulfate solution and concentrated under reduced pressure. The residue was subjected to column chromatography (n-hexane: ethyl acetate = 5: 1) to obtain Compound 3 as a white solid. (0.096 g, 85%).
References:
KR2016/20674,2016,A Location in patent:Paragraph 0050; 0067; 0068
53-16-7
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23880-57-1
8 suppliers
$140.00/5mg