ChemicalBook CAS DataBase List 3-Phenoxy-pyrrolidine

3-Phenoxy-pyrrolidine synthesis

2synthesis methods

Product Name:3-Phenoxy-pyrrolidine
CAS Number:21767-14-6
Molecular formula:C10H13NO
Molecular Weight:163.22

TERT-BUTYL 3-PHENOXYPYRROLIDINE-1-CARBOXYLATE

83220-74-0
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21767-14-6
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Yield:21767-14-6 67%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane;

Steps:

8.3 Step-3 Synthesis of 3-phenoxypyrrolidin (4)

To a solution of 3 (600 mg, 2.28 mmol) in 1 ,4-dioxane (10 mL), 4 M HCI in dioxane (5mL) was added. After completion (monitored by TLC), the reaction mixture was concentrated in vacuo to give 3-phenoxypyrrolidin (4, 250 mg, 67%) as an oily mass. LCMS: mlz 164.12 (M+H)⁺ (ES+), 91%

References:

WO2022/133529,2022,A1 Location in patent:Paragraph 0302; 0322; 0325

Pyrrolidine, 3-phenoxy-, 2,2,2-trifluoroacetate (1:1)

83220-81-9
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21767-14-6
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References