3-(Phenoxymethyl)benzonitrile synthesis

5synthesis methods

Product Name:3-(Phenoxymethyl)benzonitrile
CAS Number:57928-72-0
Molecular formula:C14H11NO
Molecular Weight:209.24

28188-41-2 Synthesis

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108-95-2 Synthesis

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Yield:57928-72-0 97%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 20; for 16 h;

Steps:

575

3-Bromomethylbenzonitrile (5.00 g, 25.5 mmol) was dissolved in N,N-dimethylformamide (50 ml_), phenol (2.40 g, 25.5 mmol) and potassium carbonate (10.6 g, 77 mmol) were added. The mixture was stirred at room temperature for 16 hours. The mixture was poured into water (400 ml_) and extracted with ethyl acetate (2 x 200 ml_). The combined organic extracts were washed with water (2 x 100 ml_), dried (MgSO₄) and evaporated jn vacuo to afford 5.19 g (97 %) 3-(phenoxymethyl)benzonitrile as an oil.TLC: R_f = 0.38 (Ethyl acetate/heptane = 1 :4)

References:

WO2006/82245,2006,A1 Location in patent:Page/Page column 260

108-95-2 Synthesis

108-95-2
723 suppliers
$14.00/25g

57928-72-0
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inquiry

References

3958-57-4 Synthesis