3-Phenylpentane-1,3,5-tricarboxylic acid synthesis
- Product Name:3-Phenylpentane-1,3,5-tricarboxylic acid
- CAS Number:17724-90-2
- Molecular formula:C14H16O6
- Molecular Weight:280.27
16320-20-0
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Yield:17724-90-2 72%
Reaction Conditions:
with water monomer;sodium hydroxide in tetrahydrofuran at 70; for 3 h;
Steps:
2.2 (2) Synthesis of compound formula 1-6-3
Add 400ml of tetrahydrofuran and 25.0g of compound formula 1-6-2 into the three-necked flask, dissolve 60.5g of sodium hydroxide in 100ml of water and add it to tetrahydrofuran, heat up to 70°C and reflux, stir for 3h, TLC detects compound formula 1- After 6-2 is completely consumed, heating is stopped, and 1M hydrochloric acid is added to acidify to pH<3 after being reduced to room temperature, and the solvent is removed by concentration, and the obtained solid is washed with water to neutrality,Purified by silica gel column to obtain 22.6 g of compound formula 1-6-3 with a yield of 72%.
References:
CN113816929,2021,A Location in patent:Paragraph 0044; 0049-0051
1146-14-1
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17724-90-2
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103-79-7
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