ChemicalBook CAS DataBase List 3-PIPERIDIN-1-YLBENZONITRILE

3-PIPERIDIN-1-YLBENZONITRILE synthesis

7synthesis methods

Product Name:3-PIPERIDIN-1-YLBENZONITRILE
CAS Number:175696-74-9
Molecular formula:C12H14N2
Molecular Weight:186.25

2156-71-0
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6952-59-6 Synthesis

6952-59-6
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175696-74-9
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Yield:175696-74-9 92%

Reaction Conditions:

Stage #1: 3-cyanobromobenzenewith TurboGrignard in tetrahydrofuran at 0; for 3 h;
Stage #2: N-chloropiperidinewith N,N,N,N,-tetramethylethylenediamine in tetrahydrofuran at -40 - 0;chemoselective reaction;

References:

Hatakeyama, Takuji;Yoshimoto, Yuya;Ghorai, Sujit K.;Nakamura, Masaharu [Organic Letters,2010,vol. 12,# 7,p. 1516 - 1519] Location in patent:supporting information; experimental part

6952-59-6 Synthesis

6952-59-6
352 suppliers
$9.00/10g

175696-74-9
39 suppliers
inquiry

References