3-Piperidinamine, 1-(methylsulfonyl)-, (3S)- synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 6 h / -15 - 20 °C
2.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C
2.2: 0.17 h / 5 °C

References:

R?hm, Sandra;Berger, Benedict-Tilman;Schr?der, Martin;Chatterjee, Deep;Mathea, Sebastian;Joerger, Andreas C.;Pinkas, Daniel M.;Bufton, Joshua C.;Tjaden, Amelie;Kovooru, Lohitesh;Kudolo, Mark;Pohl, Christian;Bullock, Alex N.;Müller, Susanne;Laufer, Stefan;Knapp, Stefan [Journal of Medicinal Chemistry,2021,vol. 64,# 18,p. 13451 - 13474]