(3-PYRID-4-YLPHENYL)METHANOL synthesis

Yield:85553-55-5 75 %

Reaction Conditions:

with tetrakis(triphenylphosphine) palladium⁽⁰⁾;sodium carbonate in 1,4-dioxane;water at 80 - 100;Inert atmosphere;Suzuki Coupling;

Steps:

5.1.5 General procedure E for Suzuki coupling reactions

General procedure: Aryl halide (1 equiv), aryl boronic acid (1.2 equiv), Na₂CO₃ (3 equiv) and Pd(PPh₃)₄ (0.05 equiv) were protected by N₂. 1,4-dioaxne/H₂O=3:1 (0.1M) was added by syringe and the solution was stirred at 100°C overnight. After cooling to room temperature, the reaction mixture was extracted with ethyl acetate for 3 times. The combined organic layer was dried over anhydrous Na₂SO₄. After removal of the drying agent, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to afford the desired product.

References:

Chen, Cheng;Guo, Shi-Meng;Sun, Yuanjun;Li, He;Hu, Nan;Yao, Kun;Ni, Huxin;Xia, Zhikan;Xu, Bin;Xie, Xin;Long, Ya-Qiu [European Journal of Medicinal Chemistry,2023,vol. 251,art. no. 115267]