3-Pyridazinamine, 6-phenoxy- synthesis
2synthesis methods
- Product Name:3-Pyridazinamine, 6-phenoxy-
- CAS Number:39539-69-0
- Molecular formula:C10H9N3O
- Molecular Weight:187.2
Yield:39539-69-0 27%
Reaction Conditions:
with sodium hydroxide in water monomer at 190; for 16 h;Sealed tube;
Steps:
121.A 6-phenoxypyridazin-3-amine
A solution of 6-chloropyridazin-3 -amine (1.3 g, 10 mmol), phenol (3.8 g, 40 mmol), and NaOH (1.6 g, 40 mmol) in water (10 mL) was stirred at 190 °C in a sealed tube for 16 h. The mixture was dispersed between EtOAc and water. Another reaction on the same scale was carried out. The organic layers were combined, concentrated to dryness, and purified by flash column chromatography to yield the title compound (0.50 g, 27% yield).
References:
WO2017/100668,2017,A1 Location in patent:Page/Page column 266; 267
