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3-Pyridinemethanol,5-ethyl-(9CI) synthesis
- Product Name:3-Pyridinemethanol,5-ethyl-(9CI)
- CAS Number:98664-62-1
- Molecular formula:C8H11NO
- Molecular Weight:137.179
![2-Chloro-5-ethylnicotinaldehyde](/CAS/20180703/GIF/863215-21-8.gif)
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Yield:98664-62-1 87%
Reaction Conditions:
with hydrogen;sodium acetate;palladium dichloride in methanol at 35; under 760.051 Torr; for 3 h;
Steps:
Typical procedures: 6-bromonicotinaldehyde (930 mg, 5.0 mmol), NaOAc (820 mg, 10.0 mmol), MeOH (30 mL), and PdCl2 (45 mg) were mixed in a glass bottle capped with a balloon filled with hydrogen. After stirred at 35 °C for 4 h, the mixture was filtered and washed with MeOH. The solvent was removed and the residue was dissolved in water, neutralized with solid NaHCO3, and extracted with ethyl acetate. The organic phase was dried over anhyd Na2SO4, and then filtered. The solvent was removed and the residue was subjected to chromatography to yield pyridin-3-ylmethanol (428 mg, 78%).
References:
Chen, Xi-Bo;Hu, Qiu-Peng;Yuan, Qian-Jia;Ding, Wei;Ren, Jiangmeng;Zeng, Bu-Bing [Tetrahedron Letters,2012,vol. 53,# 29,p. 3798 - 3801] Location in patent:experimental part
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![dimethyl pyridine-3,5-dicarboxylate](/CAS/GIF/4591-55-3.gif)
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$57.00/2g
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![5-Acetylnicotinic acid methyl ester](/CAS/GIF/38940-61-3.gif)
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