ChemicalBook CAS DataBase List 3-Pyridinesulfonamide

3-Pyridinesulfonamide synthesis

5synthesis methods

Product Name:3-Pyridinesulfonamide
CAS Number:2922-45-4
Molecular formula:C5H6N2O2S
Molecular Weight:158.18

42899-76-3 Synthesis

Pyridine-3-sulfonyl chloride hydrochloride

42899-76-3
170 suppliers
$13.43/1gm:

2922-45-4
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$31.00/100mg

Yield:2922-45-4 91%

Reaction Conditions:

with ammonia in methanol;dichloromethane at 20; for 0.833333 h;

Steps:

79.1

Example 79; N-(6-(2-(pyridine-5-sulfonamido)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide; Step 1. Pyridine-3 -sulfonamide; Pyridine-3-sulfonyl chloride HCl (647.2 mg, 3.023 mmol) was suspended in DCM (9.0 mL) and NH₃ (5 mL, 7N in MeOH, 35 mmol) was added. The reaction was stirred at RT under nitrogen for 50 minutes and then filtered, and the solid was washed with DCM. The filtrate was concentrated and dried under high vacuum to provide pyridine-3 -sulfonamide (477 mg , 91% yield). MS (ESI pos. ion) m/z: 159(MH+). Calculated exact mass for C₅H₆N₂O₂S: 158.

References:

WO2009/17822,2009,A2 Location in patent:Page/Page column 64

16133-25-8 Synthesis