3-(tert-Butyl)-1-iodoimidazo[1,5-a]pyrazin-8-amine synthesis
- Product Name:3-(tert-Butyl)-1-iodoimidazo[1,5-a]pyrazin-8-amine
- CAS Number:1320267-01-3
- Molecular formula:C10H13IN4
- Molecular Weight:316.14
1211524-21-8
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Yield:1320267-01-3 66%
Reaction Conditions:
with ammonium hydroxide at 80; for 6 h;Microwave irradiation;
Steps:
70
Intermediate 0 (76 mg, 0.22 mmol) and NH4OH were heated to 80 °C for 6 h in a microwave. The reaction mixture was concentrated in vacuo and purified using silica gel chromatography with a hexane/EtOAc gradient to yield Intermediate P (76 mg, 66% yield). ?-NM (300 MHz, CDC13) δ 1.32 (s, 9H), 5.28 (br s, 2H), 7.06 (d, 1H, J= 5.1 Hz), 7.21 (d, lH, J= 5.1 Hz). MS (ESI) (M+H)+ 317.1.
References:
WO2011/94628,2011,A1 Location in patent:Page/Page column 109
771581-15-8
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89283-32-9
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1320266-96-3
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