3-(TRIFLUOROMETHOXY)BENZALDEHYDE OXIME synthesis

Yield:928063-99-4 88.05%

Reaction Conditions:

with hydroxyamino hydrochloride;triethylamine in dichloromethane at 0 - 20; for 0.75 h;Inert atmosphere;

Steps:

400.1 Step 1: Synthesis of W2

To a solution of W1 (1.0 g, 5.26 mmol) and hydroxylamine hydrochloride (402 mg, 5.79 mmol) in DCM (25 mL) TEA (586 mg, 5.79 mmol) was added dropwise at 0 °C under N2 atmosphere, and the resulting mixture was stirred at room temperature for 45 minutes. The mixture was then diluted with water (25 mL) and extracted with DCM (25 mL) twice. The combined organic layers were separated, washed with brine (30 mL), dried over anhydrous Na2SC>4, filtered and concentrated to dryness under reduced pressure to give crude compound W2 (950 mg, 88.05% yield) which was used in the next step without any further purification. LC/MS (ESI) m/z: 206 (M+H)⁺.

References:

WO2022/192370,2022,A1 Location in patent:Page/Page column 219