ChemicalBook CAS DataBase List 3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-2-CARBALDEHYDE

3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-2-CARBALDEHYDE synthesis

5synthesis methods

Product Name:3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-2-CARBALDEHYDE
CAS Number:223575-93-7
Molecular formula:C14H9F3O
Molecular Weight:250.22

(3-(Trifluoromethyl)phenyl)magnesium bromide, 0.25 M in THF

402-26-6
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2-Propanamine, N-[(2-methoxyphenyl)methylene]-2-methyl-

82632-38-0
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3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-2-CARBALDEHYDE

223575-93-7
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$90.40/1g

Yield:223575-93-7 79%

Reaction Conditions:

Stage #1: N-tert-butyl-1-(2-methoxyphenyl)methaniminewith chromium dichloride in tetrahydrofuran at 25; for 0.0833333 h;Schlenk technique;Inert atmosphere;
Stage #2: 3-(trifluoromethyl)phenylmagnesium bromide in tetrahydrofuran at 25; for 5 h;Schlenk technique;Inert atmosphere;
Stage #3: with hydrogenchloride in tetrahydrofuran;water at 25; for 3 h;Schlenk technique;Inert atmosphere;

References:

Cong, Xuefeng;Tang, Huarong;Zeng, Xiaoming [Journal of the American Chemical Society,2015,vol. 137,# 45,p. 14367 - 14372] Location in patent:supporting information