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ChemicalBook CAS DataBase List 3-(Trifluoromethyl)-5-(2-pyridyl)-1,2,4-triazole

3-(Trifluoromethyl)-5-(2-pyridyl)-1,2,4-triazole synthesis

4synthesis methods
-

Yield:219508-27-7 52%

Reaction Conditions:

Stage #1: 2-Cyanopyridine;2,2,2-trifluoroacetohydrazide in ethanol at 20; for 0.5 h;
Stage #2: with sodium methylate in methanol;ethanol at 130; for 14 h;Reflux;

References:

Park, Hea Jung;Kim, Ji Na;Yoo, Hyun-Ji;Wee, Kyung-Ryang;Kang, Sang Ook;Cho, Dae Won;Yoon, Ung Chan [Journal of Organic Chemistry,2013,vol. 78,# 16,p. 8054 - 8064]