![](/CAS/GIF/300552-48-1.gif)
PYRIDO[4,3-D]PYRIMIDINE, 5,6,7,8-TETRAHYDRO-2-PHENYL-, MONOHYDROCHLORIDE synthesis
- Product Name:PYRIDO[4,3-D]PYRIMIDINE, 5,6,7,8-TETRAHYDRO-2-PHENYL-, MONOHYDROCHLORIDE
- CAS Number:300552-48-1
- Molecular formula:C13H14ClN3
- Molecular Weight:247.73
![2-Phenyl-6-boc-7,8-dihydro-5H-pyrido[4,3-d]pyriMidine](/CAS/GIF/300552-47-0.gif)
300552-47-0
7 suppliers
$300.00/1g
![PYRIDO[4,3-D]PYRIMIDINE, 5,6,7,8-TETRAHYDRO-2-PHENYL-, MONOHYDROCHLORIDE](/CAS/GIF/300552-48-1.gif)
300552-48-1
9 suppliers
inquiry
Yield:300552-48-1 256 mg (>100%)
Reaction Conditions:
with hydrogenchloride in ethyl acetate;
Steps:
101.D Step D:
Step D: 2-Phenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine hydrochloride To a solution of 2-phenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylic acid tert-butyl ester (prepared according to the method of Example 101, Step C, 304 mg, 0.98 mmol) in ethyl acetate (2 mL) was added hydrogen chloride (2.5 M in ethyl acetate, 3.9 mL, 9.76 mmol). This mixture was stirred at room temperature for 16 h and concentrated to give 256 mg (>100%) of the title compound of Example 101, Step D as a pale yellow solid. 1H NMR (CD3OD, 400 MHz) δ8.75 (s, 1H), 8.42-8.38 (c, 2H), 7.51-7.45 (c, 3H), 4.48 (s, 2H), 3.68 (t, 2H) 3.35-3.25 (buried, 2H); MS (APCI) 212 (MH+).
References:
US6414149,2002,B1