ChemicalBook CAS DataBase List 8-Nonenoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (2S)-

8-Nonenoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (2S)- synthesis

13synthesis methods

Product Name:8-Nonenoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (2S)-
CAS Number:300831-21-4
Molecular formula:C14H25NO4
Molecular Weight:271.35

924307-76-6 Synthesis

924307-76-6
64 suppliers
$105.00/250mg

24424-99-5 Synthesis

24424-99-5
824 suppliers
$13.50/25G

8-Nonenoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (2S)-

300831-21-4
75 suppliers
$88.00/1g

Yield: 85%

Reaction Conditions:

with triethylamine in tetrahydrofuran;water at 15 - 25; for 5 h;

Steps:

5 Example 5:
1.5 g of the compound of formula G 1.0 eq, TEA 2.2 g 2.5 eq,Di-tert-butyl dicarbonate 2.01 g 1.05 eq, THF/ H2O 7.5mL / 2.5mL, reaction at 15 ~ 25 ° C for 5h, add EA 5mL,2N HCl adjusts pH = 6.5, phase separation, aqueous phase with EA 5mL*3 extraction, drying with anhydrous sodium sulfate, filtration and desolvation,Obtained white solid 2.02g, yield 85%

References:

Zhejiang Jiuzhou Pharmaceutical Technology Co., Ltd.;Ye Wenfa;Sun Hai;Li Min CN108689909, 2018, A Location in patent:Paragraph 0069; 0070

24424-99-5 Synthesis

24424-99-5
824 suppliers
$13.50/25G