1H-Isoindole-1,3(2H)-dione, 2-(2-methylethyl)- (9CI) synthesis
- Product Name:1H-Isoindole-1,3(2H)-dione, 2-(2-methylethyl)- (9CI)
- CAS Number:304-19-8
- Molecular formula:C12H13NO2
- Molecular Weight:203.24
Yield:304-19-8 91%
Reaction Conditions:
with dipotassium peroxodisulfate in water at 100; for 0.166667 h;Microwave irradiation;Green chemistry;
Steps:
General procedure for microwave reaction
General procedure: Amide (1.0 mmol), amine (1.0 mmol) and K2S2O8 (1.5 mmol) were charged in microwave vial added water (2.0 mL), the reaction mixture was treated at 100°C and 100W for 10 min. After the complete conversion (by TLC) of the amine, distilled water (10 mL) was added and extracted with ethyl acetate (2 ×10 mL). The combined organic phase was dried over Na2SO4, and then concentrated using rotary vacuum evaporator. The crude product was purified by column chromatography (30% Ethyl acetate/hexane) to get pure compound.
References:
Srinivas, Mahesuni;Hudwekar, Abhinandan D.;Venkateswarlu, Vunnam;Reddy, G. Lakshma;Kumar, K. A. Aravinda;Vishwakarma, Ram A.;Sawant, Sanghapal D. [Tetrahedron Letters,2015,vol. 56,# 33,p. 4775 - 4779] Location in patent:supporting information
201230-82-2
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