3-[4-(2-CHLORO-6-FLUOROBENZYL)PIPERAZINO]PROPYLAMINE synthesis

Yield:306934-74-7 99%

Reaction Conditions:

Stage #1: {[3-(4-(2-chloro-6-fluoro-benzyl)piperazin-1-yl)]propyl}carbamic acid benzyl esterwith trimethylsilyl iodide in acetonitrile at 20; for 0.25 h;
Stage #2: with methanol in acetonitrile; for 0.166667 h;

References:

Jhansi Lakshmi;Suneel Kumar;Nayana, Ravi Shasi;Srinivas Mohan;Bolligarla, Ramababu;Das, Samar K.;Uday Bhanu;Kondapi, Anand K.;Ravikumar, Muttineni [Bioorganic and Medicinal Chemistry,2009,vol. 17,# 16,p. 6040 - 6047] Location in patent:experimental part