![](/CAS/20180601/GIF/31184-84-6.gif)
(E)-3-(4-chlorophenyl)-1-(2,4-dimethoxyphenyl)prop-2-en-1-one synthesis
- Product Name:(E)-3-(4-chlorophenyl)-1-(2,4-dimethoxyphenyl)prop-2-en-1-one
- CAS Number:31184-84-6
- Molecular formula:C17H15ClO3
- Molecular Weight:302.75
![4-Chlorobenzaldehyde](/CAS/GIF/104-88-1.gif)
104-88-1
611 suppliers
$5.00/25g
![2,4-Dimethoxyacetophenone](/CAS/GIF/829-20-9.gif)
829-20-9
232 suppliers
$10.00/5g
![(E)-3-(4-chlorophenyl)-1-(2,4-dimethoxyphenyl)prop-2-en-1-one](/CAS/20180601/GIF/31184-84-6.gif)
31184-84-6
7 suppliers
$495.45/5MG
Yield:31184-84-6 92%
Reaction Conditions:
Stage #1: 4-chlorobenzaldehyde;2’,4’-dimethoxyacetophenonewith sodium hydroxide in ethanol;lithium hydroxide monohydrate at 20;
Stage #2: with hydrogenchloride in lithium hydroxide monohydrate;
Steps:
2.2 General procedure for synthesis of chalcones (A1-A6)
General procedure: An aqueous solution of sodium hydroxide (10% w/v, 10ml) was added to a solution of benzaldehyde (i-iii) (0.02mol) and acetophenone (a,b) (0.02mol) in ethanol (6ml) [Scheme 1 ]. The reaction mixture was stirred at room temperature overnight and poured into water (100ml). After neutralization with hydrochloric acid (10% w:v), desired solids were obtained which were recrystallized from water-ethanol mixture.
References:
Singh, Gurjaspreet;Chowdhary, Kavita;Singh, Akshpreet;Satija, Pinky;Mohit;Pawan;Soni, Sajeev;Raghav, Neera;Sharma, Rohit [Inorganica Chimica Acta,2023,vol. 545,art. no. 121232]