(1R,2R)-2-(4-bromophenyl)Cyclopropanecarboxylic acid synthesis

3synthesis methods

Product Name:(1R,2R)-2-(4-bromophenyl)Cyclopropanecarboxylic acid
CAS Number:31501-85-6
Molecular formula:C10H9BrO2
Molecular Weight:241.08

Cyclopropanecarboxylic acid, 2-(4-bromophenyl)-, 1,1-dimethylethyl ester, (1R,2R)-

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(1R,2R)-2-(4-bromophenyl)Cyclopropanecarboxylic acid

31501-85-6
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Yield:31501-85-6 98%

Reaction Conditions:

with triethylsilane;trifluoroacetic acid in dichloromethane; for 1.5 h;

Steps:

4.5.2. Ester hydrolysis of 1 to 2

General procedure: The carboxylate esters 1 (1 equiv), TFA (13 equiv) and triethylsilane (2.5 equiv) were taken up in CH₂Cl₂. The reaction mixture was stirred for 90 min followed by concentration in vacuo. The crude material was used with no further purification or purified by flash chromatography using CH₂Cl₂ as eluent if required to provide 2.

References:

Benelkebir, Hanae;Hodgkinson, Christopher;Duriez, Patrick J.;Hayden, Annette L.;Bulleid, Rosemary A.;Crabb, Simon J.;Packham, Graham;Ganesan [Bioorganic and Medicinal Chemistry,2011,vol. 19,# 12,p. 3709 - 3716] Location in patent:experimental part

Cyclopropanecarboxylic acid, 2-(4- bromophenyl)-, ethyl ester, (1R,2R)-

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31501-85-6
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References

2039-82-9 Synthesis

2039-82-9
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References