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(1R,2R)-2-(4-bromophenyl)Cyclopropanecarboxylic acid synthesis
- Product Name:(1R,2R)-2-(4-bromophenyl)Cyclopropanecarboxylic acid
- CAS Number:31501-85-6
- Molecular formula:C10H9BrO2
- Molecular Weight:241.08
![Cyclopropanecarboxylic acid, 2-(4-bromophenyl)-, 1,1-dimethylethyl ester, (1R,2R)-](/CAS/20210305/GIF/1231764-59-2.gif)
1231764-59-2
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31501-85-6
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Yield:31501-85-6 98%
Reaction Conditions:
with triethylsilane;trifluoroacetic acid in dichloromethane; for 1.5 h;
Steps:
4.5.2. Ester hydrolysis of 1 to 2
General procedure: The carboxylate esters 1 (1 equiv), TFA (13 equiv) and triethylsilane (2.5 equiv) were taken up in CH2Cl2. The reaction mixture was stirred for 90 min followed by concentration in vacuo. The crude material was used with no further purification or purified by flash chromatography using CH2Cl2 as eluent if required to provide 2.
References:
Benelkebir, Hanae;Hodgkinson, Christopher;Duriez, Patrick J.;Hayden, Annette L.;Bulleid, Rosemary A.;Crabb, Simon J.;Packham, Graham;Ganesan [Bioorganic and Medicinal Chemistry,2011,vol. 19,# 12,p. 3709 - 3716] Location in patent:experimental part
![Cyclopropanecarboxylic acid, 2-(4- bromophenyl)-, ethyl ester, (1R,2R)-](/CAS/20210111/GIF/207279-37-6.gif)
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![(1R,2R)-2-(4-bromophenyl)Cyclopropanecarboxylic acid](/CAS/GIF/31501-85-6.gif)
31501-85-6
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![4-Bromostyrene](/CAS/GIF/2039-82-9.gif)
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$10.00/1g
![(1R,2R)-2-(4-bromophenyl)Cyclopropanecarboxylic acid](/CAS/GIF/31501-85-6.gif)
31501-85-6
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