1-[1-(methylsulfonyl)piperidin-4-yl]methanamine hydrochloride synthesis

Yield:-

Reaction Conditions:

with hydrogenchloride in ethyl acetate at 15 - 30;

Steps:

24

Reference Example 24; 1-[1-(methylsulfonyl)piperidin-4-yl]methanamine hydrochloride; [Show Image] To a solution of tert-butyl (piperidin-4-ylmethyl)carbamate (5.00 g) and triethylamine (6.27 mL) in THF (200 mL) was slowly added methanesulfonyl chloride (2.86 g) at 0°C, and the mixture was stirred overnight at room temperature. To the reaction solution was added ethyl acetate, and the mixture was washed with water and saturated brine, dried over sodium sulfate, and concentrated under reduced pressure. The residue was dissolved in ethyl acetate (100 mL), 4N hydrogen chloride-ethyl acetate solution (25 mL) was added thereto, and the mixture was stirred overnight at room temperature. The solvent was evaporated under reduced pressure to give the title compound (4.17 g, yield 78%) as a white solid. ¹H NMR (300 MHz, DMSO-d₆) δ: 1.17-1.29 (2 H, m), 1.69-1.76 (1 H, m), 1.81-1.85 (2 H, m),2.63-2.74 (4 H, m),2.86 (3 H, s), 3.53-3.57 (2 H, m), 8.16 (3 H, br).

References:

EP2261213,2010,A1 Location in patent:Page/Page column 47