2-Pyridinecarboximidamide,N-hydroxy-5-methoxy-(9CI) synthesis

Yield:327056-65-5 79 mg (24%)

Reaction Conditions:

with sodium hydroxide;hydroxylamine hydrochloride in ethanol;

Steps:

1 5-Methoxypyrid-2-ylamidoxime

Using the general procedure for the synthesis of amidoximes, 2-cyano-5-methoxypyridine (270 mg, 2.01 mmol), a solution of hydroxylamine hydrochloride (0.457 ml of 5 M, 2.28 mmol) in ethanol (4 mL), and sodium hydroxide (0.230 mL of 10 N, 2.30 mmol) were heated at reflux for 24 hours. Standard work up afforded 79 mg (24%) of 5-methoxypyrid-2-ylamidoxime.

References:

US2003/55085,2003,A1