ChemicalBook CAS DataBase List Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate

Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate synthesis

5synthesis methods

Product Name:Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate
CAS Number:328086-60-8
Molecular formula:C13H22N2O5
Molecular Weight:286.33

Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production in the process. It can be synthesized from L-Glutamic acid through five-step reaction.

L-Glutamic acid, 4-(2-aminoethyl)-N-[(1,1-dimethylethoxy)carbonyl]-, 1,5-dimethyl ester, (4S)-

328086-58-4
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Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate

328086-60-8
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Yield:328086-60-8 90%

Reaction Conditions:

with triethylamine in tetrahydrofuran; for 8 h;Reflux;

Steps:

1-2

The intermediate 2 prepared above was dissolved in 40.0 ml of tetrahydrofuran, added with 10.0 ml of triethylamine, heated under reflux for 8 hours, and then cooled to room temperature. 30.0 ml of saturated saline was added for quenching. The layers were left to stand, and the organic layer was dried and concentrated. The crude product was purified by column chromatography to obtain 4.68 g of the product with a yield of 90.0%. The product is: (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propionic acid methyl ester.

References:

CN114605301,2022,A Location in patent:Paragraph 0032; 0036; 0037; 0038; 0040-0042

328086-57-3 Synthesis