2-chloro-3-[4-(3,4-dichlorophenyl)-1-piperazinyl]naphthoquinone synthesis

1synthesis methods

Product Name:2-chloro-3-[4-(3,4-dichlorophenyl)-1-piperazinyl]naphthoquinone
CAS Number:329778-23-6
Molecular formula:C20H15Cl3N2O2
Molecular Weight:421.7043

117-80-6
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2-chloro-3-[4-(3,4-dichlorophenyl)-1-piperazinyl]naphthoquinone

329778-23-6
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Yield:329778-23-6 45%

Reaction Conditions:

in chloroform; for 8 h;

Steps:

General Procedure 1

General procedure: 1,4-NQ 1 and nuchleophilies (2, 4, 6, 8, 10, 12 and 14) were stirred in chloroform (50 mL) for 8 h. Chloroform (3x40 mL) was added to the reaction mixture. The organic layer was washed with water (100 mL), and dried with CaCl₂. After the solvent was evaporated the residue was purified by column chromatography with solvents.

References:

Gokmen, Zeliha;Onan, Mehmet Erdi;Deniz, Nahide Gulsah;Karakas, Didem;Ulukaya, Engin [Synthetic Communications,2019,vol. 49,# 21,p. 3008 - 3016] Location in patent:supporting information