N-methoxy-N-methyl-3,5-bis(trifluoromethyl)benzamide synthesis
2synthesis methods
- Product Name:N-methoxy-N-methyl-3,5-bis(trifluoromethyl)benzamide
- CAS Number:329942-69-0
- Molecular formula:C11H9F6NO2
- Molecular Weight:301.19
Yield:329942-69-0 87%
Reaction Conditions:
Stage #1: N,O-dimethylhydroxylamine*hydrochloridewith triethylamine in dichloromethane at 0;Inert atmosphere;
Stage #2: 3,5-bis(trifluoromethyl)phenyl carboxylic acid chloride in dichloromethane at 0 - 20;Inert atmosphere;
References:
Kishore Kumar;Chavarria, Gustavo E.;Charlton-Sevcik, Amanda K.;Arispe, Wara M.;MacDonough, Matthew T.;Strecker, Tracy E.;Chen, Shen-En;Siim, Bronwyn G.;Chaplin, David J.;Trawick, Mary Lynn;Pinney, Kevin G. [Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,# 4,p. 1415 - 1419] Location in patent:supporting information; experimental part
