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ChemicalBook CAS DataBase List N-De(4-sulfonaMidophenyl)-N'-(4-sulfonaMidophenyl) Celecoxib
331943-04-5

N-De(4-sulfonaMidophenyl)-N'-(4-sulfonaMidophenyl) Celecoxib synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C
1.2: 1 h
2.1: dimethyl sulfoxide / 19 h / 20 - 110 °C

References:

Hsieh, Min-Tsang;Kuo, Sheng-Chu;Lin, Hui-Chang [Advanced Synthesis and Catalysis,2015,vol. 357,# 4,p. 683 - 689]

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