1-(TERT-BUTYL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE synthesis

6synthesis methods

Product Name:1-(TERT-BUTYL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE
CAS Number:338391-69-8
Molecular formula:C15H16FN5
Molecular Weight:285.32

5-AMINO-1-(TERT-BUTYL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE

320422-34-2
21 suppliers
inquiry

60100-09-6
0 suppliers
inquiry

1-(TERT-BUTYL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE

338391-69-8
8 suppliers
inquiry

Yield:338391-69-8 81.1%

Reaction Conditions:

at 180; for 3 h;

Steps:

2.B.D

5-Amino-l-ter/-butyl-3-(4-fluoro-phenyl)-lH-pyrazole-4-carbonitrile (0.82 g, 3.16 mmol) was mixed with formamide (5 ml) and the mixture heated at 180° C under a nitrogen atmosphere for 3 hr. Upon cooling, the product separated as crystalline material which was separated by filtration, washed with water and dried to afford the title compound (0.73 g, 81.1 %); LC/MS, API-ES, Pos, (M+H)⁺, 286.1.

References:

WO2007/126841,2007,A2 Location in patent:Page/Page column 72