1H-Indole-2-carboxylicacid,4-amino-,ethylester(9CI) synthesis
- Product Name:1H-Indole-2-carboxylicacid,4-amino-,ethylester(9CI)
- CAS Number:33858-35-4
- Molecular formula:C11H12N2O2
- Molecular Weight:204.23
4993-93-5
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Yield:33858-35-4 93%
Reaction Conditions:
with hydrogen in ethanol at 20; under 3102.97 Torr; for 1.5 h;
Steps:
8.A Step A ethyl 4-amino- 1 H-indole-2-carboxylate
Step A ethyl 4-amino- 1 H-indole-2-carboxylate [00200] To a solution of ethyl 4-nitro-1 H-indole-2-carboxylate (1 .7 g, 7.3 mmol) in ethanol was added Raney nickel and the reaction hydrogenated at 60 psi at room temperature for 1.5 h. The reaction was filtered through celite and concentrated in vacuo to afford the title compound (1 .38 g, 93% yield). LC-MS: ESI (M + H)+ m/z = 205.46.
References:
WO2013/59559,2013,A2 Location in patent:Paragraph 00200