(1-cyclopropyl-Methanoyl)-diMethylaMino-acrylic acid Methyl ester synthesis
1synthesis methods
- Product Name:(1-cyclopropyl-Methanoyl)-diMethylaMino-acrylic acid Methyl ester
- CAS Number:340774-26-7
- Molecular formula:C10H15NO3
- Molecular Weight:197.23
Yield:340774-26-7 97%
Reaction Conditions:
at 80; for 1 h;
Steps:
7 Intermediate 41
[00479] To methyl 4-methyl-3-oxopentanoate (1.98 ml, 13.87 mmol) was added 1,1- dimethoxy-N,N-dimethylmethanamine (2.21 ml, 16.65 mmol) and the solution was stirred at 80 °C for 1 h. The reaction mixture was concentrated in vacuo to afford methyl-2- [(dimethylamino)methylidene]-4-methyl-3-oxopentanoate (2.76 g, 95%) as an orange oil. [00480] Method A: LC-MS m/z = 200.0 [M + H]+; RT = 1.00
References:
WO2017/59191,2017,A1 Location in patent:Paragraph 00477-00480