ChemicalBook CAS DataBase List 3,5-Pyridinedicarboxylicacid, 4-(2-chlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester

3,5-Pyridinedicarboxylicacid, 4-(2-chlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester synthesis

7synthesis methods

Product Name:3,5-Pyridinedicarboxylicacid, 4-(2-chlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
CAS Number:34148-67-9
Molecular formula:C19H22ClNO4
Molecular Weight:363.84

141-97-9 Synthesis

141-97-9
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$5.00/25g

89-98-5 Synthesis

89-98-5
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$16.00/25g

3,5-Pyridinedicarboxylicacid, 4-(2-chlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester

34148-67-9
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Yield:34148-67-9 95%

Reaction Conditions:

with 1%Cu/ZnO;ammonium acetate in water; for 0.7 h;Reflux;Green chemistry;

Steps:

General experimental procedure for 1,4-DHPs formation catalyzed by Cu-doped ZnO nanocrystalline powder

General procedure: A mixture of benzaldehyde (1 mmol), ethyl acetoacetate or acetyl acetone (2 mmol), ammonium acetate (1 mmol), and 10 mol% of Cu-doped ZnO nanocrystalline powder was refluxed in water (5 ml). The reaction process was monitored by TLC (n-Hexane: EtOAc, 1:1). Upon completion of the transformation, the reaction mixture was cooled to room temperature and extracted with CH₂Cl₂ (3 x 5 ml). The organic layer was washed with brine and water and dried over Na₂SO₄. After evaporation of the solvent, the crude yellow products were purified by crystallization from ethanol to afford 1,4-DHP derivatives in high to excellent yields.

References:

Alinezhad, Heshmatollah;Mohseni Tavakkoli, Sahar [Research on Chemical Intermediates,2015,vol. 41,# 9,art. no. 1712,p. 5931 - 5940]