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ChemicalBook CAS DataBase List Benzoic acid, 3-amino-4-(ethylamino)-, methyl ester (9CI)

Benzoic acid, 3-amino-4-(ethylamino)-, methyl ester (9CI) synthesis

4synthesis methods
-

Yield:-

Reaction Conditions:

with hydrogen;palladium(II) hydroxide in methanol at 20; for 5 h;

Steps:

4.1.5 General procedure for intermediate 4

General procedure: Intermediate of 3 (5g), 160mL of ethanol, and Pd hydroxid (1.6g) was stirred under atmosphere of hydrogen gas for 5h. The mixture was filtered through nylon and concentrated to give 3.9g of 4 as a brown liquid.

References:

Xu, Yu-Ling;Lin, Hong-Yan;Ruan, Xu;Yang, Sheng-Gang;Hao, Ge-Fei;Yang, Wen-Chao;Yang, Guang-Fu [European Journal of Medicinal Chemistry,2015,vol. 92,p. 427 - 438]