Methyl 6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylate synthesis
- Product Name:Methyl 6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylate
- CAS Number:350014-18-5
- Molecular formula:C11H13NO3
- Molecular Weight:207.23
91523-50-1
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$45.00/250mg
75-36-5
563 suppliers
$17.92/100G
350014-18-5
16 suppliers
$448.00/1g
Yield:350014-18-5 75%
Reaction Conditions:
in methanol;
Steps:
7 1,2,3,4-Tetrahydro-6-hydroxy-1-isoquinolinecarboxylic acid methyl ester
1,2,3,4-Tetrahydro-6-hydroxy-1-isoquinolinecarboxylic acid methyl ester A suspension of 1,2,3,4-tetrahydro-6-hydroxy-1-isoquinolinecarboxylic acid (5.0 g, 25.9 mmol, prepared according to W. K. Anderson, H. L. McPherson, J. S. New and A. C. Rick, Journal of Medicinal Chemistry, Vol. 27, p. 1321, 1984) in methanol (150 mL) was treated with acetyl chloride (3 mL) (reaction mixture became homogenous) and heated under reflux for 24 hours. The reaction mixture was then cooled to room temperature and concentrated in vacuo. It was diluted with ethyl acetate and washed with saturated sodium bicarbonate solution and water. After drying over anhydrous magnesium sulfate, the solvent was removed in vacuo to yield the title compound (4.0 g, 75%) as a colorless solid, mp 214-216° C.
References:
US6262068,2001,B1
67-56-1
738 suppliers
$9.00/25ml
91523-50-1
78 suppliers
$45.00/250mg
350014-18-5
16 suppliers
$448.00/1g
67-56-1
738 suppliers
$9.00/25ml
38449-59-1
19 suppliers
$50.00/10mg
298-12-4
449 suppliers
$5.00/25g
350014-18-5
16 suppliers
$448.00/1g
1700-37-4
243 suppliers
$9.00/1g
350014-18-5
16 suppliers
$448.00/1g
24550-32-1
9 suppliers
$259.00/5g
350014-18-5
16 suppliers
$448.00/1g