ChemicalBook CAS DataBase List TERT-BUTYL 4-(4-AMINOBENZOYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

TERT-BUTYL 4-(4-AMINOBENZOYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE synthesis

6synthesis methods

Product Name:TERT-BUTYL 4-(4-AMINOBENZOYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE
CAS Number:350684-49-0
Molecular formula:C16H23N3O3
Molecular Weight:305.37

TERT-BUTYL 4-(4-NITROBENZOYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

509073-62-5
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TERT-BUTYL 4-(4-AMINOBENZOYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

350684-49-0
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Yield:350684-49-0 100%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in methanol at 20; under 760.051 Torr; for 18 h;

Steps:

21

[0260j A mixture of tert-butyl 4-(4-nitrobenzoyl)piperazine- 1 -carboxylate (20 g, 60 mmol) and 10% Pd/C (4 g) in MeOH (600 mL) was stirred under 1 atmosphere of H2 at room temperature for for 18 h. The solution was filtered through Celite and the filtrate was concentrated under reduced pressure to afford 18 g of tert-butyl 4-(4- aminobenzoyl)piperazine-1-carboxylate as a white solid (100%).

References:

WO2013/177536,2013,A2 Location in patent:Paragraph 0260

150-13-0 Synthesis