ChemicalBook CAS DataBase List 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carboxaldehyde

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carboxaldehyde synthesis

5synthesis methods

Product Name:1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carboxaldehyde
CAS Number:350797-55-6
Molecular formula:C22H24N2O5
Molecular Weight:396.44

496-15-1 Synthesis

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1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carboxaldehyde

350797-55-6
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Yield:-

Steps:

Multi-step reaction with 5 steps
1.1: triethylamine / N,N-dimethyl-formamide / 20 - 50 °C
1.2: 6 h / 100 °C
2.1: trichlorophosphate / 0.67 h / cooling with ice
2.2: 3 h / 20 °C
2.3: 0.5 h
3.1: ammonium acetate / 1 h / Reflux
4.1: ethanol; sodium tetrahydroborate / tetrahydrofuran / 1.5 h / 20 °C / cooling with ice
4.2: 1 h / pH 4
5.1: trichlorophosphate / 0.83 h / cooling with ice
5.2: 2.58 h / 50 °C

References:

WO2011/124704,2011,A1