2-(CHLOROMETHYL)-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID HYDROCHLORIDE synthesis
- Product Name:2-(CHLOROMETHYL)-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID HYDROCHLORIDE
- CAS Number:351226-57-8
- Molecular formula:C9H7ClN2O2
- Molecular Weight:210.62
79-11-8
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$27.00/25g
619-05-6
290 suppliers
$19.00/25g
351226-57-8
14 suppliers
$45.00/50mg
Yield:351226-57-8 88%
Reaction Conditions:
with hydrogenchloride for 4 h;Reflux;
Steps:
General method for the Synthesis of 5 substituted-2-(chloromethyl)-1H-benzimidazole 1(a-d)
General procedure: A mixture of 4-(un)substituted-o phenylenediamine (0.05 mole) and chloroacetic acid (0.05 mole) was dissolved in ( 25 ml) 4N HCl and refluxed for 4 hrs. The completion of the reaction was checked by using T.L.C (mobile phase: ethylacetate: hexane 2:1). The reaction mixture was allowed to cool down and neutralized with ammonium hydroxide solution, the precipitate appeared was dried and recrystallized from (methanol/water).
References:
Redayan, Muayed Ahmed;Ali, Wassan Baqir;Mohammed, Ahmed Mudhafar [Oriental Journal of Chemistry,2017,vol. 33,# 6,p. 3138 - 3143]
619-05-6
290 suppliers
$19.00/25g
351226-57-8
14 suppliers
$45.00/50mg