1,3,5-Triazine-2,4-diamine, 3,6-dihydro-N2,N2,6-trimethyl-, hydrochloride (1:1) synthesis
- Product Name:1,3,5-Triazine-2,4-diamine, 3,6-dihydro-N2,N2,6-trimethyl-, hydrochloride (1:1)
- CAS Number:352211-11-1
- Molecular formula:C6H14ClN5
- Molecular Weight:191.66
105-57-7
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Yield:352211-11-1 81.4%
Reaction Conditions:
with toluene-4-sulfonic acid in 2-methyl-propan-1-ol; for 6 h;Product distribution / selectivity;Reflux;Industry scale;
Steps:
1.B
B) Synthesis according to the invention: A mixture of 1002.6 g of metformin hydrochloride, 359.1 g of paraldehyde and 51.6 g of toluene-4-sulfonic acid monohydrate in 2405.9 g of isobutanol was heated under reflux for 6 hours. Some of the solvent was removed by distillation. The mixture was cooled to 12°C, and the white precipitate was separated off, giving 953.8 g (81.4 %) of 4-amino-3,6-dihydro-2-dimethylamino-6-methyl-1 ,3,5-triazine hydrochloride.
References:
WO2010/66901,2010,A2 Location in patent:Page/Page column 38-39
1115-70-4
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123-63-7
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352211-11-1
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