3,6-Difluoro-pyrazine-2-carboxylic acid Methyl ester synthesis
- Product Name:3,6-Difluoro-pyrazine-2-carboxylic acid Methyl ester
- CAS Number:356783-26-1
- Molecular formula:C6H4F2N2O2
- Molecular Weight:174.1
356783-14-7
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356783-26-1
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Yield:356783-26-1 14.3 g
Reaction Conditions:
with potassium fluoride;tetrabutylammomium bromide in N,N-dimethyl-formamide at 80; for 15 h;Inert atmosphere;
Steps:
1.3
(3) Add 15g potassium fluoride and 6g tetrabutylammonium bromide to 200mL DMF, add 18g compound C, under nitrogen protection, and react at 80 for 15h. TLC detects the disappearance of the raw material point. Cool the reaction solution to room temperature and add Extract with water and ethyl acetate, combine the organic phases, add silica gel powder, and separate by a chromatographic column to obtain 14.3 g of light yellow liquid to obtain compound D with a purity of 99.2% and a yield of 94.5%;
References:
CN113135862,2021,A Location in patent:Paragraph 0005; 0013-0015
79-37-8
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356783-15-8
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16298-03-6
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1458-03-3
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356783-26-1
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